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  1. C52: Assessing risk of bias (Mandatory) Assess the risk of bias for each study result contributing to an outcome in the ‘summary of findings’ table. For randomized trials, the RoB 2 tool should be used, involving judgements and support for those judgements across a series of domains of bias, as described in the Handbook.

  2. Cochrane China为用户提供系统综述、控制试验、方法学、摘要、经济评估和卫生技术评估的在线平台。

  3. II.1.4 Cochrane protocols. Preparing a Cochrane Review is complex and involves many judgements. All Cochrane Reviews must have a written protocol, specifying in advance the scope and methods to be used by the review, to assist in planning and reduce the risk of bias in the review process (see Chapter 1, Section 1.5 for a detailed discussion of the rationale for protocols).

  4. Solutions. UpToDate Industry-leading clinical decision support; Ovid The world’s most trusted medical research platform; UpToDate Lexidrug Evidence-based drug referential solutions; Simplifi+ Pharmacy Compliance An automated suite of compliance solutions to optimize your operations; View All Solutions

  5. The results of 10 randomized, double blind, placebo controlled trials demonstrate that treatment for 6 months, with donepezil, galantamine or rivastigmine at the recommended dose for people with mild, moderate or severe dementia due to Alzheimer's disease produced improvements in cognitive function, on average -2.37 points (95%CI -2.73 to -2.02, p<0.00001), in the midrange of the 70 point ADAS ...

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  7. It can be difficult to link multiple reports from the same study, and review authors may need to do some ‘detective work’. Multiple sources about the same trial may not reference each other, do not share common authors (Gøtzsche 1989, Tramèr et al 1997), or report discrepant information about the study design, characteristics, outcomes, and results (von Elm et al 2004, Mayo-Wilson et al ...

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