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Anticuerpos anti-Jo-1 El anticuerpo anti-Jo-1 está dirigido contra la enzima histidil-ARNt transferasa. Dicho anticuerpo, asociado a la presencia de otros anticuerpos anti-ARNt sintetasa se encuentra en pacientes con miositis que se caracterizan por presentar artritis, fenómeno de Raynaud, fiebre y enfermedad pulmonar intersticial, definiendo ...
22 de jul. de 2023 · Anti-Jo-1 autoantibodies, directed against the histidyl-tRNA synthetase, are routinely detected in a quantitative way (ELISA or laser bead immunoassays) or in a qualitative/semi-quantitative way (immunoblots). They are the most commonly detected autoantibodies in patients’ sera who have ASS [ 3 ].
22 de jul. de 2023 · Anti-Jo-1 autoantibodies are essential markers in the diagnosis of antisynthetase syndrome (ASS), a rare inflammatory myopathy. This study shows that their concentrations and fluctuations are correlated with disease activity and severity, especially in the pulmonary system.
20 de abr. de 2022 · Anti-Ro52 antibodies frequently co-exist with anti-Jo1 antibodies with an estimated 72% co-existence. The cooccurrence is linked with increased mechanics hands, malignancy, and poorer outcome than if anti-Jo1 alone was present, often with an increased severity of ILD when present.
Hace 1 día · Anti–Jo-1 antibody, usually found in ~15% to 25% of idiopathic inflammatory myopathy patients, is still the most common anti–aminoacyl-tRNA synthetase antibody; all others typically occur in 0.5% to 10% of patients. 4, 5 Importantly, previous studies have shown that anti–full-length Jo-1 antibody levels significantly correlate with myositis core-set measures and extramuscular disease ...
Classic MSAs known for over 30 years include antibodies to Jo-1 (histidyl transfer RNA (tRNA) synthetase) and other aminoacyl tRNA synthetases (ARS), anti-Mi-2, and anti-signal recognition particle (SRP). Anti-Jo-1 is the first autoantibodies to ARS detected in 15–25 % of patients.
Anti-Jo-1 antibody is a myositis specific autoantibody most commonly found in patients with idiopathic inflammatory myopathies (IIM). This antibody is directed against the histidyl-tRNA synthetase which catalyses the binding of the histidine to its cognate tRNA during protein synthesis.
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