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  1. Hace 4 días · The FGFR signaling pathway is integral to cellular activities, including proliferation, differentiation, and survival. Dysregulation of this pathway is implicated in numerous human cancers, positioning FGFR as a prominent therapeutic target. Here, we conduct a comprehensive review of the function, signaling pathways and abnormal alterations of FGFR, as well as its role in tumorigenesis and ...

  2. Hace 18 horas · Improvement in the survival rate of gastric cancer, a prevalent global malignancy and the leading cause of cancer-related mortality calls for more avenues in molecular therapy. This work aims to ...

  3. Hace 1 día · Cancer pain guidelines assert that clinicians should ascertain patient goals for pain management which address quality of life and include patient-specific goals for comfort, mood, function, reduction of side effects, and safety with reassessment at every clinical encounter or as needed [. 2. , 4. ].

  4. Hace 5 días · Patients in step 1 completed a QOL measure (Functional Assessment of Cancer Therapy–Lung [FACT-L]; range, 0-136, with higher scores indicating better QOL) every 6 weeks for up to 18 months after enrollment. ... Get unlimited access and a printable PDF ($40.00) ...

  5. Hace 18 horas · Any concomitant systemic therapy intended for the treatment of cancer, whether health authority-approved or experimental, is prohibited. Permitted medications considered necessary for a participant’s welfare according to the local investigator include growth factors in accordance with ASCO guidelines for secondary prophylaxis and steroids as anti-emetics or part of symptom management [ 22 ].

  6. Hace 2 días · Covalent organic frameworks (COFs) have been explored for photodynamic therapy (PDT) of cancer, but their antitumor efficacy is limited by excited state quenching and low reactive oxygen species generation efficiency. Herein, we report a simultaneous protonation and metalation strategy to significantly enhance the PDT efficacy of a nanoscale two-dimensional imine-linked porphyrin-COF. The ...

  7. Hace 18 horas · In order to circumvent this major roadblock, we designed and synthesized naphthalene-derived endoperoxides with mitochondria targeting triphenylphosphonium moieties. Here, we show that these compounds release singlet oxygen by thermal cycloreversion, and initiate cell death with IC50 < 10 μM in cancer cell cultures.

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