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24 de may. de 2022 · Co-occurring rearrangements of BCL6 and MYC would support the diagnosis of high grade B cell lymphoma with MYC and BCL2 and / or BCL6 rearrangements. The morphologic, immunophenotypic and cytogenetic findings are diagnostic of DLBCL, NOS, with a germinal center B cell phenotype (answer C).
High level of c-MYC gene amplification by FISH is seen in radiation induced and chronic lymphedema associated angiosarcoma (Curr Urol Rep 2018;19:4) Some tumors harbor recurrent PTPRB and PLCG1 mutations, which are involved in angiogenesis (Curr Urol Rep 2018;19:4)
11 de feb. de 2020 · Definition / general. Clinically aggressive, mature B cell lymphoma. Small to medium sized lymphoid cells (monomorphic, except in pleomorphic variant) Essential features. Associated with t (11;14) (q13;q32) or IGH/CCND1 and cyclin D1 overexpression. Terminology. Obsolete names: Centrocytic lymphoma ( Br J Cancer Suppl 1975;2:29 )
11 de nov. de 2015 · MYC, a potent oncogene located at chromosome locus 8q24.21, was identified initially by its involvement in Burkitt lymphoma with t (8;14) (q24;q32). MYC encodes a helix-loop-helix transcription factor that accentuates many cellular functions including proliferation, growth and apoptosis.
5 de dic. de 2013 · MYC is a potent oncogene initially identified as the target of the t (8;14) (q24;q32) chromosome translocation in Burkitt lymphoma. MYC gene alterations have been identified in other mature B-cell neoplasms that are usually associated with an aggressive clinical behavior.
9 de ago. de 2021 · Introduction. MYC (mostly referred to as c-Myc) is a super-transcription factor encoded by the MYC gene located at chromosome 8 q24.21 [ 1 ]. The MYC oncoproteins (C-myc, N-myc, and L-myc) controls the transcription of nearly 15% of expressed genes [ 2 ].
5 de abr. de 2017 · c-MYC is one of the most essential transcriptional factors, regulating a diverse array of cellular functions, including proliferation, growth, and apoptosis. Dysregulation of c-MYC is essential in the pathogenesis of a number of B-cell lymphomas, but is rarely reported in T-cell lymphomas.
