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This simple algorithm picks a target iteratively by maximizing the number of domain sequences that can be modeled based on at least 30% sequence identity to the selected target structure.
- Nature Reviews Cancer
Erkki Ruoslahti, Doug Hanahan and colleagues have used a...
- Nature Reviews Cancer
1 de ene. de 2004 · Erkki Ruoslahti, Doug Hanahan and colleagues have used a phage-display model to investigate these changes and to identify new therapeutic targets.
21 de abr. de 2011 · Nature Reviews Cancer - Inhibition of Myc activity in tumour cells induces the collapse of the tumour microenvironment.
1 de oct. de 2024 · The comprehensive fishing and identification of protein target(s) consist of three key steps: (1) probe design and synthesis, (2) target fishing and protein identification, (3) target confirmation and validation.
1 de nov. de 2022 · This review proposes new strategies that focus on elucidating the mechanisms of natural products and their target proteins, hoping to provide insights into the development of new drugs based on natural products.
29 de mar. de 2012 · Swedish researchers have used an in vitro screen to evaluate the target selectivity of a panel of small molecule PARP inhibitors. The findings could eventually lead to next-generation PARP inhibitors that have a better therapeutic index than inhibitors currently in the cancer clinic.
Target 3, colloquially known as “30x30”, specifically calls for the effective protection and management of 30% of the world’s terrestrial, inland water, and coastal and marine areas by the year 2030. Put simply, 30x30 is the biggest conservation commitment the world has ever seen.
