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Hace 4 días · Abstract. Sex-biased demography, including sex-biased survival or migration, can alter allele frequency changes across the genome. In particular, we can expect different patterns of genetic variation on autosomes and sex chromosomes due to sex-specific differences in life histories, as well as differences in effective population size, transmission modes, and the strength and mode of selection.
Hace 16 horas · The risk allele frequency of rs10069690 and rs12974508 was 0.61 and 0.60 in populations of African ancestry, higher than the 0.26 and 0.48 frequencies in populations of European ancestry, ...
Hace 2 días · A: Allele frequencies are important in population genetics because they can provide information about the genetic diversity of a population. They can also be used to track changes in allele frequencies over time, which can be helpful for understanding the effects of selection, mutation, and gene flow. Q: How can allele frequencies be used to ...
Hace 4 días · An allele is one of two or more versions of DNA sequence (a single base or a segment of bases) at a given genomic location. An individual inherits two alleles, one from each parent, for any given genomic location where such variation exists.
Hace 16 horas · Because no common functional alleles were lost, it is likely that any adaptive processes in response to the disease may still occur in the reinforced population, perhaps even with greater efficiency due to reduced genetic drift (due to larger population size).
Hace 3 días · 10 May 2024. For 30 years, APOE4 has ranked as the strongest genetic risk factor for Alzheimer’s disease, with two copies boosting the odds up to 15-fold. Now, scientists make the case that people with two APOE4 alleles are not merely at risk, but are destined to develop AD. As reported in Nature Medicine on May 6, researchers led by Juan ...
Hace 2 días · The other variants of BRCA2 splice site 6145–6841 + 144del 841 and BRCA2 deletion exon 11-intron11 with low allele frequency were considered subclonal variants. Concerning the other genome profiling, mutation profile between Genome 1 and Genome 2–3 was completely different, ...
