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Alfa 1 microglobulina placentaria (PAMG-1) esta proteína fue aislada en 1975 en el líquido amniótico por el Dr. Petruin. 1 . Historia. La PAMG-1 está presente en sangre, en el flujo vaginal de la mujer embarazada y en el líquido amniótico.
Placental alpha microglobulin-1 (PAMG-1) is a human protein that was first isolated in 1975 from amniotic fluid.
The PAMG-1 test had the highest positive likelihood ratio of 20.6 for the prediction of spontaneous delivery for both 7 and 14 days, compared with phIGFBP-1 (3.1 for 7 days and 2.9 for 14 days) and cervical length <25 mm (1.8 for 7 days and 1.7 for 14 days).
30 de jun. de 2021 · These non-invasive tests are deemed to detect amniotic fluid-specific proteins with accuracy, even in the presence of cervical-vaginal fluid. Initial first-generation immunoassays were meant to utilise the monoclonal antibody approach to detect IGFBP-1 and PAMG-1 .
The PAMG-1 test demonstrated high efficacy in identifying women at risk of imminent PTL within 7 days of testing, despite being performed immediately after TVUS. High NPV can prevent improper admission and unnecessary therapies for mother and fetus.
Detection of the PAMG-1 in the vaginal fluid using AmniSure(®) test is an accurate method to diagnose rupture of the fetal membranes, with high sensitivity, specificity, negative and positive predictive values.
18 de feb. de 2020 · PAMG-1 test showed a higher accuracy rate for prediction of delivery within ≤48 and ≤7 days in comparison with cervical length of <25 mm and number of contractions. Also, PAMG-1 test had a higher positive likelihood ratio for deliveries at ≤37 weeks.
